Preclinical Study Shows Microbicide Gel's Effectiveness against HIV and Other Viruses

Population Briefs, August 2014 | Go to article overview

Preclinical Study Shows Microbicide Gel's Effectiveness against HIV and Other Viruses


Results of a recent animal study offer new optimism for microbicides, biomedical products being developed to protect people against sexually transmitted infections (STIs), including HIV. Population Council scientists and their partners have found that a proprietary microbicide gel developed by the Council is safe, stable, and can prevent the transmission of HIV, herpes simplex virus 2 (HSV-2), and human papillomavirus (HPV), in both the vagina and rectum in animals. It has a window of efficacy in the vagina against all three viruses of at least eight hours prior to exposure. An in vitro study also provides the first data that the gel is effective against multiple strains of HIV.

The gel, known as MZC, contains MIV-150, zinc acetate, and carrageenan. MIV-150 and zinc acetate are potent antiviral agents that inhibit HIV via different mechanisms of action. MIV-150 is an enzyme inhibitor that blocks an early step of HIV replication in target cells, and zinc acetate is an antiviral agent with demonstrated activity against HIV and HSV-2. These compounds are mixed in a water-based solution of carrageenan, a compound derived from seaweed that has been shown to have potent activity against HPV. Infection with HSV-2 or HPV is associated with increased risk of HIV infection. Researchers believe that microbicides that target HIV, HSV-2, and HPV may more effectively limit HIV transmission than those that target HIV alone.

In this study, Council scientists and their partners used macaque and mouse models to examine whether MZC gel could prevent vaginal and rectal transmission of SHIV-RT (a virus combining genes from HIV and SIV, the monkey version of HIV), HSV-2, and HPV. They found that MZC:

* protected macaques against vaginal SHIVRT infection when applied up to 8 hours prior to challenge

* protected macaques against rectal SHIV-RT infection when used close to the time of viral challenge

* protected mice against HSV-2 infection when applied vaginally or anally/rectally just before a high dose of virus

* protected mice against HSV-2 when applied between 8 hours before and 4 hours after vaginal challenge with a low dose of HSV-2

* protected mice against HPV when applied up to 24 hours before and 2 hours after vaginal challenge and also if applied 2 hours before or after HPV inoculation of the anus/rectum. …

The rest of this article is only available to active members of Questia

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Note: primary sources have slightly different requirements for citation. Please see these guidelines for more information.

Cited article

Preclinical Study Shows Microbicide Gel's Effectiveness against HIV and Other Viruses
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen
Items saved from this article
  • Highlights & Notes
  • Citations
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Search by... Author
    Show... All Results Primary Sources Peer-reviewed

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.