Investigation of the PhoPR Two-Component Signal Transduction System in Bacillus Subtilis, Staphylococcus Aureus and Staphylococcus Epidermidis

By Prunty, Michael | Journal of the Statistical and Social Inquiry Society of Ireland, Annual 2018 | Go to article overview

Investigation of the PhoPR Two-Component Signal Transduction System in Bacillus Subtilis, Staphylococcus Aureus and Staphylococcus Epidermidis


Prunty, Michael, Journal of the Statistical and Social Inquiry Society of Ireland


Part 1 of 3

Statutory Declaration

I declare that this thesis has not been submitted as an exercise for a degree at this or any other university and is entirely my own work, except where it is duly acknowledged in the text.

I agree to deposit this thesis in the University's open access institutional repository or allow the library to do so on my behalf, subject to Irish Copyright Legislation and Trinity College Library conditions of use and acknowledgement.

Acknowledgements

I would like to sincerely thank my supervisor Prof. Kevin Devine whose experience, knowledge and encouragement have ensured this project would succeed. I have thoroughly enjoyed working together and I especially enjoyed our discussions which have led to many exciting experiments and results!

I would also like to thank all the other members of the Devine lab, both past and present, for their support and advice throughout my research. Dr. David Noone, Dr. Susanne Krogh-Devine, Dr. Letal Salzberg and especially Dr. Eric Botella who taught me many, if not all, of the most important techniques that enabled me to carry out my research successfully. I would also like to thank Laura Uelze for her support, coffee and conversations throughout. It has always been a pleasure to go to work in the Devine lab.

Thanks also to the technical and administrative staff at the Dept. of Genetics for all of their varied and appreciated assistance along the way.

I would also like to thank Dr. Joan Geoghegan and members of the Staphylococcal research group in the Moyne for their guidance and advice on the world of S. aureus! Thanks also to Dr. Carsten Kroger for his assistance in carrying out RNA sequencing, and Dr. Karsten Hokamp and Dr. Darren Fitzpatrick for their assistance with the analysis.

I am grateful to my thesis committee, Prof. Peter Humphries and Dr. Frank Wellmer, who took the time to help assess and guide my research project.

I would also like to thank my family and friends for their continuous support and encouragement throughout not only this project but also my entire education. I would especially like to thank my parents and sisters who have always ensured that I was never limited in what I could do and supported me in any way possible throughout.

Finally, to my partner Leanne, I cannot thank you enough. Without your constant support and friendship every step of the way this would not have been possible. Ti amo!

This work was supported by a studentship from Science Foundation Ireland as part of Principal Investigator award

12/1A/1570 to Prof. Kevin M. Devine.

Publications

Manuscript in preparation

Prunty, M.P., Noone, D., Devine, K.M. (2017) The distinct PhoPR mediated responses to phosphate limitation in Bacillus subtilis subspecies subtilis and spizizenii stem from differences in anionic polymer composition and metabolism.

Manuscript in preparation

Prunty, M.P., Fitzpatrick, D.J., Hokamp, K., Kroger, C., Geoghegan, J.A., Devine, K.M. (2017) An investigation of the PhoPR two-component system in Staphylococcus aureus.

Contents

Declaration                                                            i
Acknowledgements                                                      ii
Summary                                                              iii
Publications                                                           v
List of Tables                                                        xi
List of Figures                                                     xiii
List of Abbreviations                                              xviii
1. Chapter 1 - Introduction                                            1
  1.1 Bacillus subtilis                                                2
  1.2 Staphylococci                                                    3
  1.3 The Cell Envelope                                                4
    1.3.1 Cell envelope structure                                      4
    1. … 

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