Clinical Trial Seeks to Stop 'Wasting' in Colon Cancer Patients

News Sentinel, May 31, 2013 | Go to article overview

Clinical Trial Seeks to Stop 'Wasting' in Colon Cancer Patients


The clinical trial is for advanced-stage colon cancer patients, but the result could help solve a problem common to those who have all kinds of cancer.

The University of Tennessee Medical Center is enrolling patients in a Phase III trial testing whether a certain drug can stop or slow cachexia, the loss of lean muscle tissue, said UTMC oncologist Wahid Hanna, principal investigator. Such "wasting" is a problem not only for cancer patients, but also for patients with other serious, chronic illnesses, such as AIDS -- and no one knows what causes it or how to definitively stop it, Hanna said.

"The body, instead of building up (lean muscle tissue) starts breaking down," resulting in steady, significant weight loss, Hanna said. "The quality of life will deteriorate. This study is designed to try to reverse that."

The study, sponsored by Texas-based antibody therapy company XBiotech Inc., looks at whether the antibody MABp1 (in the form of an intravenous drug, Xilonix) can stop or reverse cachexia, prolonging the survival of, in this case, advanced colorectal cancer patients. The company wants to enroll 656 patients before the study ends in December 2014.

"I'm very intrigued" by the study, of which UTMC is the lead site in this region, Hanna said. "The effect can be apparent within eight weeks, a very short period of time, which is very dramatic."

In order to qualify, patients must be 18 or older with pathologically confirmed colorectal cancer that is metastatic or cannot be surgically removed. They must be able to take in oral nutrition and can't have a serious additional medical disorder or infection, and they must have lost 5 percent or more of their body weight over the past six months.

In addition, they must have tried and failed to respond to the two standard treatments for cachexia.

Hanna said it's common for the standard treatments -- types of chemotherapy drugs -- to work for a while, then suddenly stop working. …

The rest of this article is only available to active members of Questia

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Note: primary sources have slightly different requirements for citation. Please see these guidelines for more information.

Cited article

Clinical Trial Seeks to Stop 'Wasting' in Colon Cancer Patients
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen
Items saved from this article
  • Highlights & Notes
  • Citations
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Search by... Author
    Show... All Results Primary Sources Peer-reviewed

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.