A summary of current clinical articles from that pile on your desk
Human Papillomavirus Load Linked to Cervical Cytology
J Natl Cancer Inst. 2009;101:153-161. [February 4, 2009]
Levels of human papillomavirus-18 DNA in cervical tissue are only associated with the severity of cervical cytology in women who do not go on to develop a precursor to cervical cancer, according to researchers at the University of Washington in Seattle. The researchers found that during two years of follow-up, 304 percent of women developed cervical intraepithelial neoplasia grade 2-3. HPV-18 DNA load was associated with increasing severity of cervical cytology at baseline only in women who did not develop CIN2-3. Among women who had low-grade or high-grade squamous intraepithelial lesions at baseline, after adjusting for age and co-infection with other high-risk HPVs, baseline HPV-18 DNA load was lower in women who developed CIN2-3. The authors conclude that testing for high levels of HPV-18 DNA does not appear to be clinically useful.
* Hormonal Therapy Link to Breast Cancer Explored
N Engl J Med. 2009;360:573-587. [February 5, 2009]
A decline in the use of combined hormone therapy appears responsible for a decreased incidence of breast cancer among women, according to researchers at the Harbor-UCLA Medical Center in Torrance, California. During the first two years of the study, fewer breast cancer diagnoses were observed among women receiving combination hormonal therapy. However, during the subsequent study years, women in the combination hormonal therapy group experienced nearly twice the incidence of breast cancer diagnoses, and this increased until the women stopped taking dieir pills, after which the elevated risk decreased rapidly. Although this decline coincided with a decreased use of hormonal therapy, there was no difference in the frequency of mammography.
* U.S. Sees Significant Rise in Diagnosed Diabetes
Diabetes Care. 2009;32:287-294. [February 2009]
Although diagnosed diabetes in adults increased in the United States in recent decades, undiagnosed diabetes and pre-diabetes remained fairly steady, according to researchers at the National Institutes of Health in Bethesda, Maryland. A recent survey found that more than 40 percent of American adults have diabetes or pre-diabetes. In adults aged 20 and older, 7.7 percent have diagnosed diabetes, and 5.1 percent have undiagnosed diabetes based on fasting plasma glucose or two-hour glucose. …