A summary of current clinical articles from that pile on your desk
Higher Breast Cancer Risk from Hormone Therapy
Obstet Gynecol 2009;113:65-73. [January 2009]
Obstet Gynecol. 2009;113:74-80. [January 2009]
Long-term use of certain types of hormonereplacement therapy is associated with an increased risk of breast cancer, according to two studies. Finnish researchers found that women using E2-progestogen therapy after three years had an increased risk of breast cancer. In the second study, researchers at the Boston University School of Medicine in Lexington, Massachusetts, found that although women using estrogen alone or esterifted estrogen with methyltestosterone were at no more risk of breast cancer than non-users, women who used conjugated estrogen, combined with progestin, were at higher risk than non-users-particularly those who were on hormonereplacement therapy for four or more years, which about tripled the risk compared with non-users.
* Garlic Has Minimal Cancer-Prevention Effects
Am J Clin Nutr. 2009;89:257-264. [January 2009]
Evidence suggests that garlic consumption has little or no effect in reducing the risk of many common cancers, South Korean researchers concluded. After conducting a review of 19 studies, the researchers found very limited evidence to support a link between garlic consumption and a reduced risk of colon, prostate, esophageal, larynx, oral, ovary, or renal cell cancers. They found no credible evidence to support a link between garlic consumption and a reduced risk of gastric, breast, lung, or endometrial cancer. * Aneurysmal Subarachnoid Hemorrhage Risks Identified
Neurology. 2009;72:69-72. [January 6, 2009]
Smoking and a family history of aneurysmal subarachnoid hemorrhage are independently associated with an increased risk of the illness, according to researchers at the University of Cincinnati College of Medicine. Compared with current non-smokers with no family history of aneurysmal subarachnoid hemorrhage, the researchers found that current non-smokers with a family history, current smokers with no family history, and current smokers with a family history had a steadily increased risk of aneurysmal subarachnoid hemorrhage.
* Cognitive Rehab Shows Some Benefit in Brain Injury
Neuropsychology. 2009;23:20-39. [January 2009]
Cognitive rehabilitation appears to have a modest effect in individuals with acquired brain injury, according to researchers at the University of South Alabama in Mobile. The authors found relatively modest, yet significant, effects from cognitive rehabilitation on global cognitive function. Treatment effects were moderated by the treatment domain, type of injury, time since the injury, and age. Attention training appeared to be effective after traumatic brain injury, as did language and visuospatial training for aphasia and neglect syndromes following stroke.
* Health-Care-Associated Cases Have More Severe Pneumonia
Ann Intern Med. 2009;150:19-26. [January 6, 2009]
Italian researchers found that patients with healthcare-associated pneumonia had more severe disease and higher mortality than those with community-acquired pneumonia. Those with health-care-associated disease had higher fatality rates (17.8 percent vs. 6.7 percent) and longer average hospital stays (18.7 days vs. 14.7 days) than patients with community-acquired pneumonia.
* Hundreds Acquired Hepatitis B, C in U.S. Health-Care Settings
Ann Intern Med. 2009;150:33-39. [January 6, 2009]
More than 400 people in the United States were found to have acquired the hepatitis B virus or hepatitis C virus in non-hospital, health-care settings since 1998, with more than 60,000 estimated to have been at risk during these outbreaks, according to investigators at the U.S. Centers for Disease Control and Prevention in Atlanta. The investigators identified 33 outbreaks: 18 resulted in 173 cases of HBV infection, 16 resulted in 275 cases of HCV infection, and 1 outbreak involved both. …