Prospects for a Helicobacter Pylori Vaccine to Treat Peptic Ulcer Disease

By Czinn, Steven J. | International Journal of Child Health and Human Development, October 1, 2013 | Go to article overview

Prospects for a Helicobacter Pylori Vaccine to Treat Peptic Ulcer Disease


Czinn, Steven J., International Journal of Child Health and Human Development


Helicobacter pylori infection is recognized as a major risk factor for the development of peptic ulcer disease and gastric cancer. Although antimicrobial therapies have been developed, successful eradication of the infection still requires the patient to take a minimum of three medications for 7-10 days. Side effects of this treatment are common, resulting in poor compliance, which reduces the effectiveness of the treatment. Finally the development of antibiotic resistant strains is becoming more common decreasing the efficacy of the therapy.

Efforts to develop a vaccine against Helicobacter pylori began in earnest in 1993. The initial attempts at vaccination were all oral (mucosal) immunizations in an effort to promote a localized mucosal immune response in the stomach. Over the past twenty years, there have been a number of improvements to this approach. There are now a number of H. pylori candidate vaccine antigens that have been used successfully to prevent or cure chronic H. pylori infection in animal models. Newer mucosal adjuvants have also been used that have reduced toxicity in humans. …

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Prospects for a Helicobacter Pylori Vaccine to Treat Peptic Ulcer Disease
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