Morbidity and Hospitalizations of Adults with Down Syndrome

By Tenenbaum, Ariel; Chavkin, Maor et al. | International Journal of Child Health and Human Development, October 1, 2013 | Go to article overview

Morbidity and Hospitalizations of Adults with Down Syndrome


Tenenbaum, Ariel, Chavkin, Maor, Wexler, Isaiah D., Korem, Maya, Merrick, Joav, International Journal of Child Health and Human Development


Over the last decade a significant increase in the life expectancy of people with Down syndrome (DS) has been observed, which has caused a higher incidence of morbidity as they age, however there is a lack of literature regarding morbidity and hospitalization of adults with DS.

Methods: Analysis of 297 hospitalizations of 120 adults with DS aged 18-73 years hospitalized at Hadassah Medical Centers during the years 1988- 2007 compared with data of the general population, hospitalized at the same period.

Results: At the age range 18-66 years, mean number of hospitalizations were significantly higher than the general population (p=0.000001) with hospitalization also significantly longer (P=0.0009). Exceptionally long hospitalizations were seen at the departments of internal medicine, dermatology and intensive care units. There was no significant difference in mortality between DS and the general population (p=0.221). More than a fourth of the hospitalizations were caused by infectious diseases, mostly respiratory infections. Hypothyroidism was found more prevalent compared with the estimated number reported by literature (30.8% vs. 15%). Convulsive disorder was found to be prevalent as well (15.8%). However, the prevalence of congenital heart disease, dementia, osteoporosis and obesity was found less than expected. …

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