New Studies Target Side Effects of Psychotropic Drugs

By Chernin, Tammy | Drug Topics, June 18, 2001 | Go to article overview

New Studies Target Side Effects of Psychotropic Drugs


Chernin, Tammy, Drug Topics


Should anyone be expected to sacrifice sexual satisfaction or experience excessive weight gain in order to obtain psychological well-being? Participants attending the 154th American Psychiatric Association annual meeting, held recently in New Orleans, tackled these issues while exploring what can be done.

Researchers reported the findings from the first study to examine the rates of sexual dysfunction among users of the new-generation antidepressants. In the overall study population of nearly 6,300 patients, bupropion sustained-release tablets (Wellbutrin SR, GlaxoSmithKline) were associated with the lowest rate of sexual dysfunction (25%), followed by bupropion HCl (Wellbutrin) (22%). Those results compared with an average of 40% for all the selective serotonin reuptake inhibitors (SSRIs), venlafaxine (Effexor, Wyeth-Ayerst), and mirtazapine (Remeron, Organon).

Sexual dysfunction can greatly impinge on a patient's quality of life, affect medication compliance, and interfere with recovery from depression, said lead investigator Anita Clayton, M.D., associate professor and vice chair of the Department of Psychiatric Medicine at the University of Virginia.

The tendency for most of the atypical antipsychotics to induce weight gain was also a hot topic at the meeting. One study reported that olanzapine (Zyprexa, Lilly) tended to produce more weight gain as compared with ziprasidone (Geodon, Pfizer). Another study observed that olanzapine-- treated patients manifested increased weight gain, fasting insulin levels, total cholesterol levels, and triglyceride levels when compared with patients on ziprasidone. However, emerging data showed that olanzapine-induced weight gain is manageable with clinical and educational intervention.

Kimberly Littrell, M.S., A.P.R.N., president and CEO of the Promedica Research Center in Atlanta, reported the findings for her small pilot study. Schizophrenic patients who participated in a four-month, one-hour-- weekly education class on nutrition and exercise gained fewer pounds compared with those receiving no behavioral interventions.

Additional data were also presented on a retrospective study of 145 psychiatric outpatients treated with olanzapine. In this study, only nine patients discontinued olanzapine treatment because of weight gain.

"What we've seen here is that treatment efficacy is a very important factor as it relates to medical adherence and, ultimately, to a favorable treatment outcome," said L. Jan Findlay, R.N., C.N. …

The rest of this article is only available to active members of Questia

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Note: primary sources have slightly different requirements for citation. Please see these guidelines for more information.

Cited article

New Studies Target Side Effects of Psychotropic Drugs
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen
Items saved from this article
  • Highlights & Notes
  • Citations
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Search by... Author
    Show... All Results Primary Sources Peer-reviewed

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.