Risk Factors for Aggressive Breast Cancer Found

By Massey, Nina | The Scotsman, November 12, 2019 | Go to article overview

Risk Factors for Aggressive Breast Cancer Found


Massey, Nina, The Scotsman


Some household detergents, antiseptics and insecticides are potential environmental risk factors and new targets for treating an aggressive form of breast cancer, scientists say.

According to new data, exposure to common everyday chemicals may increase the risk of developing a difficultto-treat type of breast cancer. However, experts say that, while the study has no clinical or public health implications, it identifies areas for new research.

Triple negative breast cancer (TNBC) is an aggressive form that particularly affects younger people and makes up 10-20 per cent of all breast cancer diagnoses.

While curable if caught early, TNBC is resistant to hormone treatments and newer targeted therapies used to treat other types of breast cancer. It is therefore treated with surgery, radiotherapy and chemotherapy.

Researchers say there is a better need to understand the biology of this aggressive form of breast cancer in order to develop new therapies, improve quality of life and identify how to reduce the risk of developing it.

Women with other types of breast cancer that are hormone receptor positive are treated with hormonal therapies which target oestrogen and progesterone receptors - two of 48 nuclear receptors (NRs).

It is known that many NRs are altered in breast cancer. This means they can be potential drivers of breast cancer development and possible therapeutic targets. …

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