|1.||The psychological trait of hostility predisposes to increased incidence of CHD, as well as deaths from all causes.|
|2.||A cluster of biobehavioral characteristics has been identified in hostile persons, which makes a strong case for the biological plausibility of hostility as a factor that would predispose to both CHD and cancer. Exciting new research is beginning to apply the tools of cell and molecular biology to strengthen this case and identify the specific proximate cellular and molecular pathways whereby hostility contributes to pathogenesis.|
|3.||The clustering of a particular set of biobehavioral characteristics in hostile persons also suggests a possible neurobiological basis for this clustering: deficient brain serotonergic function.|
|4.||Both pharmacological (to enhance brain serotonergic function) and behavioral (to improve stress-coping skills and ability to control hostility) approaches should be evaluated in clinical trials aimed first at patients already suffering from both CHD and cancer, and ultimately at healthy persons at high risk due to increased hostility.|
This chapter was supported in part by grants from The National Heart, Lung and Blood Institute (HL36587, HL44998), the National Institute of Mental Health (MH70482), and Clinical Research Unit Grant MOI-RR-30.