immunoreactivity within the MS/VDB without significantly affecting retrograde labeling of these neurons with true blue injections into their axons. Similar results were reported following fimbrial transection using preoperative fluorgold retrograde labeling of MS/VDB cholinergic neurons ( Peterson et al., 1990).
The putative role of neurodegeneration within the basal forebrain-hippocampal system in Alzheimer's disease underlies our interest in the potential role of hippocampal NTFs in this process. The results of our last experiment suggest that markers of MS/VDB neurotransmitter function are compromised by damage to hippocampal neuronal subpopulations without axotomy of MS/VDB neurons. These results are thus supportive of an important role for NTFs in the neuropathology of Alzheimer's disease.
We acknowledge the Whitehall Foundation for support for the first two experiments in this chapter. The third experiment was supported by a Scholarly and Creative Award from the University of Oregon. We also acknowledge the able assistance of Oregon students Elizabeth Kidwell, David Pardo, and Kerrie Ramsdell for much of the work reported in the section on trophic dependence. Ruth BreMiller helped with histology on all of the experiments reported here.
Anderson K. J., Dam D., Lee S., & Cotman C. ( 1988). "Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo". Nature, 234,360-361.
Arendt T., Bigl V. Tennstedt A., & Arendt A. ( 1985). "Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer's disease". Neuroscience, 14,1-14.
Ayer-LeLievre C., Olson L., Ebendal T., Seiger A., & Persson H. ( 1988). "Expression of the beta-nerve growth factor gene in hippocampal neurons". Science, 240,1339-1341.
Banker G. A. ( 1980). "Trophic interactions between astroglial cells and hippocampal neurons in culture". Science, 209,809-810.
Björklund A., & Stenevi U. ( 1977). "Reformation of the severed septo-hippocampal pathway in the adult rat by transplanted septal neurones". Cell Tissue Research, 185,289-302.
Conner J. M., Muir D., Varon S., Hagg T., & Manthorpe M. ( 1992). "The localization of nerve growth factor-like immunoreactivity in the adult rat basal forebrain and hippocampal formation". Journal of Comparative Neurology, 313,454-462.
Conner J. M., & Varon S. ( 1992). "Distribution of nerve growth factor-like immunoreactive neurons in the adult rat brain following colchicine treatment". Journal of Comparative Neurology, 326,347-362.