in one of the experiments. In a previous study ( Woodruff, Baisden, & Nonneman, 1991), TMT-treated rats given aspiration lesions and hippocampal transplants were found to be more impaired in aquisition of the water maze than rats given just TMT or given TMT and aspiration lesions without transplant tissue. Therefore, we believe that the conclusion that transplantation technique is a crucial variable is justified. Additionally, the results of our entire series of experiments indicate that the behavioral outcome of transplantation of fetal hippocampal tissue represents a complex interaction involving surgical procedure, behavioral task, and tissue type. Future research directed toward the development of transplantbased treatment of clinical disorders must address these variables. It may be the case that certain clinical manifestations of neurodegenerative disorders may be at least partially alleviated using particular transplant strategies, whereas other aspects of the same neurological disorder will prove to be intractable to this mode of treatment.
Our interest in recovery of function after damage to hippocampus or neocortex was fostered during our graduate training with Professor Robert L. Isaacson. He shared with us his tremendous enthusiasm for research into brain mechanisms of behavior and continues to provide inspiration by example. Bob has not entered directly into neurotransplantation research, but it is the type of bold venture he enjoys, and it comes as no surprise that several contributors to this area of neuroscience are related professionally to Bob. In addition to ourselves these scientists include our colleagues and collaborators Dr. Arthur J. Nonneman and Dr. Larry Means, as well as Bob's first graduate student, Dr. Daniel Kimble, and Dan's student Dr. Donald Stein. Additionally, the co-author of Dan's chapter, John Vicedomini, was a student of Art Nonneman. Dr. Fred H. Gage spent two of his undergraduate years in Bob's lab at the University of Florida and sent his student, Dr. Joe Springer, to Bob for graduate training. Dr. György Buzsáki completes the list. Of all the gifts Bob has given us, the daring to be creative is the greatest. The experiments described here that were conducted in our laboratory and the preparation of this chapter were supported by a National Institutes of Health (NIH) grant (ES 0407003-07) to MLW.
Backlund E.-O., Granberg P.-O., Harnberger B., Knutsson E., Mårtensson A., Sedvall G., Seiger A., & Olson L. ( 1985). Transplantation of adrenal medullary tissue to stiatum in parkinsonism. Journal of Neurosurgery, 62, 169-173.