The Strange Case of the Spotted Mice and Other Classic Essays on Science

By Peter Medawar | Go to book overview

12
The strange case of the spotted mice

'Can the leopard change his spots?' the prophet asked ( Jeremiah, 13:23), clearly not expecting to be told he can. Nor, indeed, can mice, except under the rather discreditable circumstances now to be outlined.

It is a well-attested truth of observation that except under special and unusual circumstances skin from one mouse or human being will not form a permanent graft after transplantation to another mouse or another human being; for although such a graft heals into place it soon becomes inflamed and ulcerated, and eventually dries up and sloughs off. The exceptional circumstances are: in human beings, when donor and recipient are identical twins, and in mice when prolonged inbreeding (e.g., upward of twenty successive generations of brother/sister mating) has made the mice so closely similar to each other genetically that they almost could be identical twins.

This being so, great surprise was caused in the world of transplantation when Dr William Summerlin, a member of the largest and in many ways the most important cancer research centre in the world, the Sloan-Kettering Institute in New York, with the backing of his chief, Dr Robert A. Good, made known in 1973 his surprising claim that a comparatively simple procedure -- 'tissueculture' -- could make a skin graft or a corneal graft from a member of the same or even of a different species acceptable to an organism that would otherwise have rejected it. This claim was specially important because grafting skin from one human being to another has never entered clinical practice, in spite of encour-

-132-

Notes for this page

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this book

This book has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this book

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this page

Cited page

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited page

Bookmark this page
The Strange Case of the Spotted Mice and Other Classic Essays on Science
Table of contents

Table of contents

  • Title Page iii
  • Foreword - The Phenomenon of Medawar v
  • Contents xiii
  • Introduction xiv
  • 1 - The Phenomenon of man 1
  • 2 - Hypothesis and imagination 12
  • 3 - Is the scientific paper a fraud? 33
  • 4 - The Act of Creation 40
  • 5 - Darwin's illness 52
  • 6 - Two conceptions of science 59
  • 7 - Science and the sanctity of life 72
  • 8 - J.B.S. 86
  • 9 - Lucky Jim 94
  • 10 - On 'the effecting of all things possible' 104
  • 11 - Further comments on psychoanalysis 120
  • 12 - The strange case of the spotted mice 132
  • 13 - Unnatural science 144
  • 14 - Florey story 162
  • 15 - In defence of doctors 170
  • 16 - Expectation and prediction 182
  • 17 - Scientific fraud 196
  • 18 - Son of stroke*** 203
  • 19 - The question of the existence of God 207
  • 20 - On living a bit longer 212
  • Notes 218
  • Sources 228
  • Index 231
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this book

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen
/ 236

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Author Advanced search

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.