CELSO-RAMON GARCIA Senior Scientist, Worcester Foundation for Experimental Biology; Chief, Infertility Clinic, Massachusetts General Hospital.
I SHALL ADDRESS my remarks to the biological control of conception and, as my title infers, mainly to those applications in the human of the more successful animal experiments where conception has been controlled through physiological means. By this I mean to exclude the various mechanical devices which had been utilized for control of conception. At the start, I have some question as to how to classify the recently reactivated intrauterine coil; although it is a mechanical device, its mechanism of action still is not clear. Whether this device acts through a local effect or an indirect physiological effect is still an unanswered question, but it is such an effective method that I felt compelled to mention it.
By biological means one might alter fertility by inhibiting implantation, by blocking fertilization, or by controlling the formation or the release of the germ cells in either sex. Within these three major groupings one can classify the various physiological methods by which the fertility of the individual may be controlled.