Research Director, Worcester Foundation for Experimental Biology; Research Professor, Boston University Graduate School.
IN ATTEMPTING to discuss frontiers in systems of fertility control, I have decided to confine myself to the more popular member of the species, namely the female. Again, at risk of appearing to be theoretical I should like to review very briefly in the course of the discussion certain basic phenomena which must be considered in the development of any method in which the female is the primary controller of fertility, Therefore, I will in part expatiate somewhat on a few things that Dr. Parkes (1) has presented and also will touch on some of the matters covered by Dr. García (2).1
To get into the subject matter at once, let us recall that from the point of view of the organization of reproductive processes in the female there are really two major steps: one is the production of the gamete, the egg, and the other is its fertilization and eventual birth. In other words, fertilization or pregnancy preceded by ovulation is shown diagrammatically in Figure 1. The system has been described by Dr. Parkes (1) and I shall briefly recall it to you. It is the system in which a hypothalamic neurohumor stimulates the adenohypophysis, i.e. the anterior pituitary,____________________