industry for producing such varied products as high-octane gasoline; cumene (a solvent used to produce phenol and acetone); ethylbenzene (a solvent used to produce styrene); better cleaning detergents; synthetic rubber; and plastics and elastomers. Many of these substances are toxic and flammable and, therefore, a little dangerous. Friedel-Crafts reactions began to be studied in 1877, but there are a large number of reactions. It took decades to study them all, and Nightingale contributed a good deal to the field through her extensive publications. Many of her articles are cited in the definitive work on the Friedel-Crafts reactions, Friedel- Crafts and Related Reactions, by George Olah.
Nightingale was concerned about the dearth of women in chemistry. She at one time urged women to teach chemistry at the junior college level to get a start in the field. She also collected statistics on women in college chemistry faculties. Nightingale also believed in being involved in professional organizations. She was a member of the American Chemical Society and past vice-president and treasurer of the Missouri section. She was a member of the American Association of University Women. Phi Beta Kappa could claim her as a member, and the local chapter elected her its vice-president. She was once also the secretary and vice- president for Sigma Xi and past vice-president and local chapter president of Sigma Delta Epsilon.
After retiring in 1972, Nightingale returned to Boulder, Colorado. She identifies herself as Christian and her hobbies as music and photography, especially the photography of wildflowers. She likes "motoring," seeing the countryside via car, horseback riding, and mountain climbing, and she is a member of the Colorado Mountain Club. She has traveled extensively in Mexico, Guatemala, and the mountainous areas of southern Europe. She has even cruised along the Antarctic peninsula. 8