Stress and Disease Processes

By Neil Schneiderman; Philip McCabe et al. | Go to book overview

these peptides may be involved in enhancing the resistance to superficial tissue damage gained during the social confrontation. In this chapter, I avoided discussing the involvement of adrenal glucocorticoids within the context of stress-induced immunomodulation. The role of glucocorticoids in immunoregulation is complex and certainly needs further elucidation. However, it should be noted that ACTH, as part of the POMC precursor, stimulates the adrenal cortex to secrete glucocorticoids. These hormones are considered to be generally immunosuppressive. Thus, part of the POMC precursor can induce immunoinhibitory signals (glucocorticoids) to terminate its own direct immunoenhancing properties. This view is in line with current thoughts of the role of glucocorticoids in the defense to stress as formulated by Munck, Guyer, and Holbrook ( 1984), stating that glucocorticoids do not protect against the source of stress itself, but rather against the body's normal reaction to stress, preventing those reactions from overshooting and themselves threatening homeostasis.


ACKNOWLEDGMENTS

I thank Dr. C Heijnen for her technical assistance in performing some of the immunological assays, Rob Binnekade for his skillful help in performing the in vivo experiments, and Janet Edmond ( Fishberg Research Center, Mount Sinai Medical Center, New York) and Henk Nordsiek for reproducing the figures. This study was supported by the Royal Dutch Academy for Sciences and Arts.


REFERENCES

Axelrod J., & Reisine T. D. ( 1984). "Stress hormones: Their interaction and regulation". Science, 224,452-459.

Berkenbosch F., Heijnen C. J., Croiset G., Revers C., Ballieux R. E., Binnekade R., & Tilders F. J. H. ( 1986). "Endocrine and immunological responses to acute stress". In N. P. Plotnikoff , R. E. Faith, & R. A. Good (Eds.), Enkephalins and endorphins: Stress and the immune system (pp. 109-118). New York, London: Plenum Press.

Berkenbosch F., Oers van J. W. A. M., Del A. Rey, Tilders F. J. H., & Beseclovsky H. O. ( 1987). "Corticotropin-releasing factor producing neurons in the rat activated by interleukin-1". Science, 238,524-526.

Berkenbosch F., Schipper J., & Tilders F. J. H. ( 1986). "Corticotropin-releasing factor immunostaining in the rat spinal cord and medulla oblongata: An unexpected form of cross reactivity with substance P". Brain Research, 399,87-96.

Berkenbosch F., & Tilders F. J. H. ( 1988). "Effects of axonal transport blockade on corticotropin releasing factor immunoreactivity in the median eminence of intact and adrenalectomized rats: Relationship between depletion rate and secretory activity". Brain Research, 442,312-317.

Berkenbosch F., Tilders F. J. H., & Vermes I. ( 1983). "Beta-adrenoceptor activation mediates stress-induced secretion of beta-endorphin and related peptides from intermediate but not anterior pituitary". Nature, 305,237-239.

-88-

Notes for this page

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this book

This book has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this book

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this page

Cited page

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited page

Bookmark this page
Stress and Disease Processes
Table of contents

Table of contents

Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this book

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen
/ 333

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Author Advanced search

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.