Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease

By Rudolph E. Tanzi; Ann B. Parson | Go to book overview

Illustrations
1.1 Genes interspersed along a chromosomexv
1.1 Three examples of variations that occur in DNA9
1.2 The site of marker G8's linkage to the Huntington's gene18
2.1 Photomicrograph of amyloid plaque in the cerebral cortex23
2.2 Photomicrograph of Alzheimer's plaques and tangles29
3.1 A gene and its intervening stretches of coding (exon) and noncoding (intron) DNA along a chromosome50
4.1 DNA to RNA to protein65
4.2 Photomicrograph of neurofibrillary tangles inside neurons69
4.3 The human cortex and its four lobes72
4.4 Amyloid gene's approximate location in relation to marker D21S183
5.1 APP protein and its A-beta segment88
5.2 APP protein and its protease inhibitor domain92
5.3 The shading indicates amino acid commonalities in the APP protease inhibitor of humans and snails96
6.1 APP protein and its A-beta snippet108
6.2 APP protein cleaved by "good" protease109
6.3 APP protein and the sites of the three secretases110
7.1 APP protein: site of the first-found Alzheimer's mutation118
7.2 The A-beta peptide and its aggregation first to fibril then to plaque125

-ix-

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Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease
Table of contents

Table of contents

  • Title Page iii
  • Contents vii
  • Illustrations ix
  • Acknowledgments xi
  • Introduction xiii
  • One - Cleave, Zap, Blot, Probe *
  • Two - The Core of the Matter 20
  • Three - Candidate Chromosome 48
  • Four - Gone Fishing 60
  • Five - Curious Gene 84
  • Six - From Famine to Feast 98
  • Seven - Mutations, Revelations 114
  • Eight - Of Mice and People 134
  • Nine - Gene Prix 146
  • Ten - The 42 Nidus 172
  • Eleven - Untangling a Cascade 190
  • Twelve - A Gamble for Hope 206
  • Epilogue 240
  • Resources 249
  • Notes 251
  • Index 269
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