A number of persons have made substantial contributions to the formulation and preparation of this book. Marc Hollender, M.D., and Bryan King, M.D., were collaborators in previously published work. Virginia Abernethy, Ph.D., Russell Gardner, Jr., M.D., Jack G. Modell, M.D., and Loren Pancratz, Ph.D., reviewed portions of this manuscript and provided provocative and innovative ideas, useful suggestions, and reference materials. Other persons with whom I have discussed ideas in the book and who have made intellectual contributions include Roy N. Aruffo, M.D., Douglas Drossman, M.D., Arthur M. Freeman III, M.D., Thomas R. Garrick, M.D., Frederick G. Guggenheim, M.D., Lisa Gonzenbach, L.C.S.W., José L. Ochoa, M.D., Ph.D., Graeme Smith, M.D., Herman Willcutt, Ph.D., and the late Robert Kellner, M.D., Ph.D. I appreciate the fine work of the editorial staff of the American Psychiatric Press, particularly the careful attention and skilled editing of the manuscript by Alisa Guerzon, Project Editor, and the enthusiasm and support for the book, since its infancy, from Claire Reinburg, Editorial Director.