Efficacy Data for
Acute Treatment of
IPT has developed through a progression of research trials and adaptations for further trials, each of which has tested its efficacy for a particular psychiatric disorder or a specific patient population. Here we describe the results of the acute treatment trials. The results for maintenance treatment of depression and for adaptations to particular age groups and other treatment populations are described in subsequent chapters.
The first test of efficacy of IPT as an acute antidepressant treatment was a four- cell, sixteen-week randomized trial of IPT, amitriptyline (AMI), their combination, and a nonscheduled control treatment for eighty-one outpatients with major depression ( DiMasdo et al., 1979; Weissman et al., 1979). This study was advanced for its time in training therapists to adhere to a treatment manual. Amitriptyline was dosed at 100-200 mg. q.d., typical doses for the time but lower than might be attempted today. The nonscheduled treatment assigned patients a psychiatrist whom they were told to contact when they felt the need. No regular treatment sessions were scheduled, but patients could telephone to arrange a session if they felt sufficient distress.