Chronic Diseases

By Marvin Stein; Andrew Baum | Go to book overview

MOLECULAR BIOLOGICAL APPROACHES

The amyloid that is deposited in the core of the senile plaque in AD is derived from a much larger precursor protein (the beta amyloid precursor protein). Excess amyloid may be formed through an abnormal cleavage (amyloidogenic) pathway in which the larger precursor protein is broken down into abnormal insoluble fragments, which aggregate to form amyloid ( Esch et al., 1990). If this is the case, elucidation of such a pathway and the offending enzyme could allow for the development of protease inhibitors that block amyloidogenesis. Although this appears to be an attractive theoretical approach, it remains unclear whether amyloid plays an important role in the pathogenesis of this disorder and whether decreasing the deposition of amyloid would alter the natural history of the illness or improve symptoms in AD patients.


CONCLUSIONS

Although there is no currently effective treatment for AD, some progress has been made in the search for agents that will produce symptomatic improvement in Alzheimer sufferers. The cholinergic hypothesis remains to be proven or refuted by the development of a cholinomimetic agent that can achieve adequate concentrations at the brain receptor site without producing toxic side effects. And, although the ideal cholinomimetic remains to be tested, currently available anticholinesterases indicate that at least a subgroup of patients show a favorable response to augmentation of this system in AD. Future studies will address the exciting possibilities posed by combination neurotransmitter approaches and modulation of brain glutamatergic and peptidergic systems. Finally, the development of peptide trophic factors will provide the opportunity to test the efficacy of trophic agents in improving symptoms and preventing further neuronal degeneration in AD.


REFERENCES

Bondareff W., Mountjoy C. Q., & Roth M. ( 1984). "Loss of neurones of origin to the adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia". Neurology, 32, 1 64)- 168.

Bowen D. M., Allen. S. J., Benton J. S., Goodhardt M. J., Haan E. A., Palmer A. M., Sims N. R. , Smith C. C.T., Spillane J. A., Esiri M. M., Neary D., Snowden S., Wilcock G. K., & Davison A. N. ( 1983). "Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy and Alzheimer's disease". Journal of Neurochemistry, 41, 266-272.

Bowen D. M., Francis P. T., Lowe S. L., Pangalos M. N., Procter. A. W., & Steele J. E. ( 1989). "Pyramidal neuron loss and Glycine-Site Therapy: A need for an animal model and study in late-life depression". Neurobiology of Aging, 10, 616-618.

Branconnier R. J. ( 1983). "The efficacy of cerebral metabolic enhances in the treatment of senile dementia". Psychopharmacology Bulletin, 19, 212-219.

-52-

Notes for this page

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this book

This book has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this book

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this page

Cited page

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited page

Bookmark this page
Chronic Diseases
Table of contents

Table of contents

Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this book

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen
/ 344

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Author Advanced search

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.